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Introduction from Medical Air Solutions

Bio-terrorism is a major concern of the Department of Homeland Security.  The information on these pages has been gathered from the Centers for Disease Control and Prevention (CDC), NIOSH, the U.S. Army Medical Research Institute of Infectious Disease (USAMRIID), the Associated Press and other sources.

There is no consensus as to what type of biological pathogen may be employed when an aerial attack occurs, but there is a list (below) of possible candidates that are the most likely.  There has been discussions on TV and in the printed press about how this type of attack will be dealt with after it occurs.

Dealing with the problem assumes that the institutions that are providing help are protected and that the personnel providing care are not themselves infected with whatever pathogen was used.  We can assist in protecting individual rooms, or provide an entire building (the EPIC System) to protect against any airborne pathogen including the man-made varieties.

Possible Bioterrorist Airborne Pathogens

Characteristics and Symptoms of Some Anti-Human Biological Agents

Name and Type of Agent

Rate of Action

Effective Dosage

Symptoms and or Effects

Prophylaxis/Treatment

Bacillus anthracis

Anthrax

Type: Bacteria

Incubation:
1 to 6 days

Length of illness:
1 to 2 days

Extremely high mortality rate

5,000 to 50,000 spores Cutaneous: Skin infections. If untreated will result in death 20% of the time.

Intestinal: Abdominal pain, vomiting of blood, severe diarrhea.  Results in death 25-60% of the time.

Inhalational: Severe breathing problems and shock.  Usually fatal.

Treatable, if antibiotics administered prior to onset of symptoms

Vaccines exist but are limited and used for military personnel.

Yersinia pestis

Plague

Type: Bacteria

Incubation:
2 to 10 days

Length of illness:
1 to 2 days

Variable mortality rate

100 to 500 organisms Malaise, high fever, tender lymph nodes, skin lesions, possible hemorrhages, circulatory failure, and eventual death Treatable, if antibiotics administered within 24 hours of onset of symptoms

Vaccine is not currently being produced in U.S.

Brucella suis

Brucellosis

Type: Bacteria

Incubation:
5 to 60 days

2% mortality rate

100 to 1,000 organisms Flu-like symptoms, including fever and chills, headache, appetite loss, mental depression, extreme fatigue, aching joints, sweating, and possibly gastrointestinal symptoms. Treatable with antibiotics

No vaccine available

Pasturella tularensis

Tularemia

(Also known as rabbit fever and deer fly fever)

Type: Bacteria

Incubation:
1 to 10 days

Length of illness:
1 to 3 weeks

30% mortality rate

10 to 50 organisms Fever, headache, malaise, general discomfort, irritating cough, weight loss Treatable, if antibiotics administered early

Without antibiotics 33% die.  A vaccine is under review by the FDA.

Coxiella burnetti

Q-fever

Type: Rickettsiae

Incubation:
2 to 14 days

Length of illness:
2 to 14 days

1% mortality rate

1 to 10 organisms Cough, aches, fever, chest pain, pneumonia Treatable with antibiotics

Vaccine available

Variola virus

Smallpox

Type: Virus

Incubation:
average 12 days

Length of illness:
several weeks

35% mortality rate in un-
vaccinated individuals

10 to 100 organisms Malaise, fever, vomiting, headache appear first, followed 2 to 3 days later by lesions

Highly infectious

Treatable if vaccine administered early

Only 12 million vaccination doses available in the U.S. at this time.

Note: World Health Organization conducted a vaccination campaign from 1967 to 1977 to eradicate smallpox.

Venezuelan equine encephalitis

Type: Virus

Incubation:
1 to 5 days

Length of illness:
1 to 2 weeks

Low mortality rate

10 to 100 organisms Sudden onset of fever, severe headache, and muscle pain

Nausea, vomiting, cough, sore throat and diarrhea can follow

No specific therapy exists

Vaccine available

Yellow fever

Type: Virus

 

Incubation:
3 to 6 days

Length of illness:
1 to 2 weeks

5% mortality rate

1 to 10 organisms Severe fever, headache, cough, nausea, vomiting, vascular complications (including easy bleeding, low blood pressure) No specific therapy exists

Vaccine available

Hemorrhagic Fevers (various strains)

Type: Virus

3-5 days

30-90% mortality rate (depending on strain)

10 to 100 organisms Fever, muscle aches, diarrhea

Hemorrhaging of fluids out of tissues and orifices (30-90% of the victims die. depending on the strain)

Some diseases respond to antiviral drugs, which are in short supply.
Saxitoxin

Produced by blue-green algae commonly ingested by shellfish, mussels in particular

Type: Toxin

Time to effect:
minutes to hours

Length of illness:
Fatal after inhalation of lethal dose
10 micrograms per kilogram of body weight Dizziness, paralysis of respiratory system, and death within minutes
 
Botulinum

Causes botulism

Produced by Clostridium botulinum bacterium

Type: Toxin

Time to effect:
24 to 36 hours

Length of illness:
24 to 72 hours

65% mortality rate

.001 microgram per kilogram of body weight Weakness, dizziness, dry throat and mouth, blurred vision, progressive weakness of muscles

Interruption of neurotransmission leading to paralysis

Abrupt respiratory failure may result in death

Treatable with antitoxin, if administered early

The CDC maintains the botulism anti-toxin supply.

Ricin

Derived from castor beans

Type: Toxin

Time to effect:
a few hours

Length of illness:
3 days

High mortality rate

3 to 5 micrograms per kilogram of body weight Rapid onset of weakness, fever, cough, fluid build-up in lungs, respiratory distress No antitoxin or vaccine available
Staphylococcal enterotoxin B  (SEB)

Produced by Staphylococcus aureus

Type: Toxin

Time to effect:
3 to 12 hours

Length of illness:
Up to 4 weeks
30 nanograms per person Fever, chills, headache, nausea, cough, diarrhea, and vomiting No specific therapy or vaccine available

An act of biological or chemical terrorism might range from dissemination of aerosolized anthrax spores to food product contamination, and predicting when and how such an attack might occur is not possible.  However, the possibility of biological or chemical terrorism should not be ignored, especially in light of events during the past 10 years (e.g., the sarin gas attack in the Tokyo subway and the discovery of military bio-weapons programs in Iraq and the former Soviet Union).

Biological agents are odorless, tasteless, and when dispersed in an aerosol cloud, are invisible to the human eye because the particle size of the aerosol is extremely small (1 to 5 microns or smaller).  Weight-for-weight, biological weapons are hundreds to thousands of times more potent than the most lethal chemical weapon, meaning that even small amounts (e.g., a few kilograms) could be used with devastating effect, whereas hundreds or thousands of tons of chemical agents could be required for militarily significant operations.

Preparing the nation to address this threat is a formidable challenge, but the consequences of being unprepared could be devastating.  The public health infrastructure must be prepared to prevent illness and injury that would result from biological and chemical terrorism, especially a covert terrorist attack.

As with emerging infectious diseases, early detection and control of biological or chemical attacks depends on a strong and flexible public health system at the local, state, and federal levels. In addition, primary health-care providers throughout the United States must be vigilant because they will probably be the first to observe and report unusual illnesses or injuries.

Considerable technical efforts are required to package live BW agents in a missile warhead and ensure that the agent is dispersed at the correct height and angle of delivery to create an airborne aerosol.  However despite these technical challenges, recent UN revelations that Iraq may have retained 16 ballistic missiles armed with BW warheads in violation of UN Resolutions underlines the serious potential threat posed by ballistic missiles armed with BW agents.

Mounting biological dispersal systems onto cruise missiles may overcome the disadvantages associated with aircraft and ballistic missile delivery systems. An aerosol dispersal system mounted on a Unmanned Aerial Vehicle (UAV), creating, in effect, a remotely piloted crop duster, would be an effective way of deploying BW agents over a determined target area.  Simply acquiring a crop dusting plane would also be possible in our free society.  The U.S. experimented with and actually built a working aerosol delivery system in the 1960s.  That such methods of biological weapons delivery are increasingly seen as practical is underlined by a recent CIA report into Iraq's pre-1991 CBW program.

Congress of the United States
U.S. Senate Foreign Relations Committee

Testimony of Donald A. Henderson, MD, MPH (excerpts)
Director, Center for Civilian Biodefense Studies
The Johns Hopkins University,
Schools of Public Health and Medicine

The Threat from Biological Weapons

Nothing in the realm of natural catastrophes or man-made disasters rivals the complex problems of response that would follow a bioweapons attack against a civilian population. The consequence of such an attack would be an epidemic and, in this country, we have had little experience in coping with epidemics. In fact, no city has had to deal with a truly serious epidemic accompanied by large numbers of cases and deaths since the 1918 influenza epidemic, more than two generations ago.

Senators Hart and Rudman, chairs of the United States Commission on National Security in the Twenty-first Century, singled out bioweapons as perhaps the greatest threat that the U.S. might face in the next century. Admiral Stansfield Turner pointed out that, besides nuclear weapons, the only other weapons with the capacity to take the nation past the "point of non-recovery" are the biological ones.

The Dark Winter scenario dramatizes the catastrophic potential of smallpox as a weapon. It is, of course, not the only possible organism that might be used. In 1993, the Office of Technology Assessment estimated that 100 kilograms of anthrax released upwind of a large American city - the model being Washington, DC - could cause between 130,000 and 3 million deaths, depending on the weather and other variables. This degree of carnage is in the same range as that forecast for a hydrogen bomb. Although there is legitimate concern as well about the possible use of chemical weapons, they are far less effective pound for pound and extremely difficult to deploy over large areas. Ten grams of anthrax can produce as many casualties as a ton of a chemical nerve agent.

The insidious manner by which a biological attack would unfold is itself alarming. The fact of an attack using an explosive or chemical weapon would be recognized immediately and resources summoned quickly to deal with the consequences and to begin to remediate the situation. A biological agent would, in all probability, be released clandestinely as an aerosol spray, odorless and invisible, which would drift slowly throughout a building or across a city. Not until days to weeks later would people begin to fall ill; new cases would continue to occur over a period of one to several weeks. Some of those exposed, in all likelihood, would be hundreds of miles away when they develop symptoms -- in other cities, in other countries. Thus, the consequence of the attack would extend well beyond the immediate area of release.

The consequences of a biological weapon attack would be an epidemic, most likely following an unannounced attack. In all probability, we would know that something had happened only when people started appearing in the emergency rooms and doctors' offices with strange maladies. Depending on the biological agent and its incubation period, it could be days or weeks after release of the organism before people first became ill. Identification of the cause could be problematical. American physicians today are not trained to diagnose illnesses due to the pathogens thought to be the ones most likely to be used as bioweapons. Few physicians have ever seen cases of anthrax or smallpox or pneumonic plague.

It is difficult to imagine how the public might respond in today's world to a fast-moving lethal epidemic. In recent decades, there have been few such epidemics in industrialized cities. One of the more recent occurred in India in 1994. Plague broke out in the diamond-polishing district of Surat. It was reported by the media as a deadly, mysterious fever, possibly plague. Within hours, panic reigned. People began streaming from the city. Many in the medical community were among the first to leave. Eventually half a million fled, leaving the city a ghost town. It is estimated that India lost some two billion dollars in lost trade, embargoes, and production as a consequence of this outbreak. How many actually died of plague is still not clear but the total was not more than 50.

Hospitals

When Americans are seriously ill, they expect to be cared for in hospitals. If the hospitals became overwhelmed and were paralyzed by chaos, it would have serious implications for public morale and for the potential for containing an epidemic, let alone treating those who were already sick. The likelihood of public anxiety rising to civil disorder would rise substantially.

Hospitals are under serious pressure today. Of the 5000 hospitals in the U.S., 30% are losing money; over the last decade, 1000 have closed because of financial reasons. They face a host of regulatory issues including those dealing with health insurance portability, safer needles, medical and medication error reduction, limits on medical device reuse, ergonomic standards for employees, requirements for patient restraints and seclusion, and many more. At the same time, the numbers of the uninsured are increasing and the population is aging and in need of more medical services. The hospitals have struggled to become ever more efficient but, in their quest to eliminate inefficiencies, they have basically wiped out their surge capacity. Even minor increases in patient demand, such as that of the 1999 brief and mild flu season strained most hospitals.

This lack of elasticity is also seen in the pharmaceutical field as companies have focused on just-in-time production and delivery. The result is that reserve supplies are few and temporary problems in production are regularly manifested in country-wide spot shortages of such as antibiotics and other critical drugs.

There is an increasing shortage of emergency rooms what with the loss of a thousand hospitals in the past decade and a desire on the part of hospitals to close ERs, if possible, because of their drain on resources. The amount of time that Baltimore's hospitals have been on "diversion" of ambulances because of over crowding has doubled every year for the past three years. Ventilators to aid respiration are in short supply. Baltimore, home to two major medical centers and medical schools, could not handle an acute situation that produced as many as 50 casualties requiring ventilators. A handful of highly contagious patients would cause havoc, there being in the Baltimore-Washington area, no more than 100 beds in negative pressure rooms that could handle highly contagious patients.

However, the most intractable problem for hospitals is likely to be staffing. As we have been told, only half of all nurses work in hospitals and the average age of a nurse in America is 53. More are now retiring than are being recruited to the field. Hospital administrators report that, even if they had more open beds, they doubt that they would have staff to care for the patients.

To see the entire text of this testimony click on the link below...

http://www.hopkins-biodefense.org/pages/library/spread.html

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